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AChE/BChE-IN-23

CAT: 0804-HY-159898Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159898Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE/BChE-IN-23 (Compound 6e) is an AChE/BChE inhibitor (IC50: 0.91 μM, 1.19 μM and 1.01 μM for hAChE, eq BChE and hBChE, respectively). AChE/BChE-IN-23 has antioxidant activity and inhibits Aβ1-42 and Tau protein aggregation. AChE/BChE-IN-23 also inhibits microglial activation by reducing ROS release and mitochondrial injury. AChE/BChE-IN-23 suppresses NLRP3 inflammasome and pro-inflammatory cytokines in human microglial cells. AChE/BChE-IN-23 also reverses the Scopolamine -induced memory impairment in mice model[1].
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; Mitochondrial Metabolism; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS) ; Tau Protein
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-bche-in-23.html
Smiles
N/C(C1=CC=CC(NC(NCCC2=CNC3=C2C=C(OC)C=C3)=O)=C1)=N\O
Molecular Formula
C19H21N5O3
Molecular Weight
367.40
References & Citations
[1]Shankar G, et al. Discovery of novel substituted (Z) -N'-hydroxy-3- (3-phenylureido) benzimidamide derivatives as multifunctional molecules targeting pathological hallmarks of Alzheimer's disease. Eur J Med Chem. 2024;280:116959.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; NLRP3

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