AChE/BChE-IN-23

CAT: 0931-MF-0061923-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0061923-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Cytochromes P450|||Beta Amyloid|||NOD-like Receptor (NLR) |||Reactive Oxygen Species|||Cholinesterase (ChE) |||Parasite|||Mitochondrial Metabolism|||ROS|||Microtubule Associated
Related Pathways
Neuroscience|||NF-?B|||Microbiology/Virology|||Metabolism|||Cytoskeletal Signaling|||Immunology/Inflammation
Bioactivity
AChE/BChE-IN-23 (Compound 6e) is a dual inhibitor of acetylcholinesterase and butyrylcholinesterase, exhibiting IC50 values of 0.91 ?M for AChE, 1.19 ?M for eqBChE, and 1.01 ?M for hBChE. This compound also demonstrates antioxidant properties and inhibits the aggregation of A?1-42 and Tau proteins. Moreover, AChE/BChE-IN-23 prevents the activation of microglial cells by inhibiting the release of reactive oxygen species and mitochondrial damage. Additionally, it reduces the levels of the NLRP3 inflammasome in human microglial cells and reverses memory impairment in mice induced by scopolamine.
Smiles
N/C(C1=CC=CC(NC(NCCC2=CNC3=C2C=C(OC)C=C3)=O)=C1)=N/O
Molecular Formula
C19H21N5O3
Molecular Weight
367.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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