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Recombinant human eIF-4H/EIF4H protein

CAT: 0112-ATGP1562-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP1562-500Size:500 µg
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Description
Eukaryotic translation initiation factor 4H, also known as EIF4H, is a 248 amino acid protein that localizes to the perinuclear region of the cytoplasm and is expressed as two isoforms, designated short and long. EIF4H induces the RNA-dependent ATP hydrolysis catalyzed by the initiation factors EIF4A and EIF4B. EIF4H was further shown to stimulate the initial rate and extent of EIF4A-mediated mRNA secondary structure unwinding. Defects in the gene encoding EIF4H are associated with Williams- Beuren syndrome (WBS), a rare developmental disorder characterized by cardiovascular and musculo-skeletal abnormalities. Recombinant human EIF4H protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Eukaryotic translation initiation factor 4H, eIF-4H, WBSCR1, WSCR1, Williams-Beuren syndrome chromosome region 1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
29.9 kDa (272aa) confirmed by MALDI-TOF
Additionnal Information
EIF4H, Eukaryotic translation initiation factor 4H, eIF-4H, WBSCR1, WSCR1, ATGP1562-10 µg, ATGP1562-20 µg, ATGP1562-50 µg, ATGP1562-100 µg, ATGP1562-250 µg, ATGP1562-500 µg, ATGP1562-1 mg, ATGP1562-10, ATGP1562-20, ATGP1562-50, ATGP1562-100, ATGP1562-250, ATGP1562-500, ATGP1562-1
References & Citations
Richter Cook N J., et al. (1998) J Biol Chem. 273:7579-7587.; ; Doepker R C., et al. (2004) J Virol. 78: 4684-4699.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_071496
Uniprot Accession Number
Q15056
Species
Human
AA Sequence
MADFDT YDDRAYSSFG GGRGSRGSAG GHGSRSQKEL PTEPPYTAYV GNLPFNTVQG DIDAIFKDLS IRSVRLVRDK DTDKFKGFCY VEFDEVDSLK EALTYDGALL GDRSLRVDIA EGRKQDKGGF GFRKGGPDDR GMGSSRESRG GWDSRDDFNS GFRDDFLGGR GGSRPGDRRT GPPMGSRFRD GPPLRGSNMD FREPTEEERA QRPRLQLKPR TVATPLNQVA NPNSAIFGGA RPREEVVQKE QE

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