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Human BRCC36/BRCC3 antibody

CAT: 0112-ATGA0159-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0159-100Size:100 µL
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Description
BRCC36 (BRCA1/BRCA2-containing complex, subunit 36) is a holoenzyme complex containing BRCA1, BRCA2. BRCC36 is an ubiquitin E3 ligase complex that has a role in DNA repair and enhances cellular survival following DNA damage. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint.
Product Name Alternative
BRCA1/BRCA2-containing complex subunit 3, chromosome X open reading frame 53, C6.1A
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant BRCC36 (1-316aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT3B1
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-G affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
BRCC36, ATGA0159-10 µg, ATGA0159-20 µg, ATGA0159-50 µg, ATGA0159-100 µg, ATGA0159-250 µg, ATGA0159-500 µg, ATGA0159-1 mg, ATGA0159-10, ATGA0159-20, ATGA0159-50, ATGA0159-100, ATGA0159-250, ATGA0159-500, ATGA0159-1
References & Citations
Wang Bin, et al., (2007) Proc Natl Acad Sci USA 104 (52) :20759-20763.; ; Chen Xiaowei, et al., (2006) Cancer Research 66:5039-5046.; ; Dong Y, et al., (2003) Mol Cell 12 (5) :1087-1099.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Ubiquitination
NCBI Accession Number
NP_077308
Uniprot Accession Number
P46736
WB Description
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BRCC36 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: HeLa cell lysate; ; Lane 2.: HepG2 cell lysate; ; Lane 3.: 293T cell lysate; ; Lane 4.: MCF7 cell lysate; ; Lane 5.: NIH3T3 cell lysate;
IF Description
ICC/IF analysis of BRCC36 in HeLa cells. The cell was stained with ATGA0159 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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