(S) - (+) -Ibuprofen

• Description :

  (S) - (+) -Ibuprofen ((S) -Ibuprofen), a S (+) -enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC50s of 2.1 μM and 1.6 μM, respectively. (S) - (+) -Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects[1][2].

• Product Name Alternative :

  Dexibuprofen

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  COX

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/_S_-__addition__-Ibuprofen.html

• Purity :

  99.99

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming)

• Smiles :

  OC([C@H](C1=CC=C(CC(C)C)C=C1)C)=O

• Molecular Formula :

  C13H18O2

• Molecular Weight :

  206.28

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Evans AM, et al. Comparative pharmacology of S (+) -ibuprofen and (RS) -ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.|[2]N Scheuren, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123 (4) :645-52.|[3]Astrid Janssen, et al. Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment. Eur J Pharmacol. 2006 Jul 1;540 (1-3) :24-33.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  COX-1; COX-2

• CAS Number :

  [51146-56-6]