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(S) - (+) -Ibuprofen

CAT: 0804-HY-78131A-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-78131A-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) - (+) -Ibuprofen ((S) -Ibuprofen), a S (+) -enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC50s of 2.1 μM and 1.6 μM, respectively. (S) - (+) -Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects[1][2].
CAS Number
51146-56-6
Product Name Alternative
Dexibuprofen
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/_S_-__addition__-Ibuprofen.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming)
Smiles
OC([C@H](C1=CC=C(CC(C)C)C=C1)C)=O
Molecular Formula
C13H18O2
Molecular Weight
206.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Evans AM, et al. Comparative pharmacology of S (+) -ibuprofen and (RS) -ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.|[2]N Scheuren, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123 (4) :645-52.|[3]Astrid Janssen, et al. Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment. Eur J Pharmacol. 2006 Jul 1;540 (1-3) :24-33.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-1; COX-2

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