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ALC-0315

CAT: 0804-HY-138170-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-138170-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine[1].
CAS Number
2036272-55-4
UNSPSC
12352211
Hazard Statement
H315, H319
Target
Liposome; SARS-CoV
Type
Oligonucleotides
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/alc-0315.html
Purity
99.72
Solubility
DMSO : 50 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)
Smiles
OCCCCN(CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCOC(C(CCCCCC)CCCCCCCC)=O
Molecular Formula
C48H95NO5
Molecular Weight
766.27
Precautions
H315, H319
References & Citations
[1]Moghimi SM. Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines. Mol Ther. 2021;29 (3) :898-900.|[2]Ferraresso F, Strilchuk AW, Juang LJ, Poole LG, Luyendyk JP, Kastrup CJ. Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells. Mol Pharm. 2022;19 (7) :2175-2182.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

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C01102-100mgALC-0315
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