BI-0319

CAT: 0804-HY-176198Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-176198Size:1 Each

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Description

BI-0319 is a selective PTK2/FAK PROTAC degrader. BI-0319 can reduce cancer cells viability inhibit proliferation and invasion. BI-0319 can be used for the research of cancer, such as liver cancer[1][2]. (Structure Note: Pink: PTK2/FAK ligand ; Blue: VHL ligand (HY-125845) ; Black: linker (HY-140189) ; VHL ligand-Linker: (HY-103602A) )

CAS Number

2341740-85-8

UNSPSC

12352005

Target

FAK; PROTACs

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C1CCC2=CC=CC(OC3=NC(NC4=C(C=C(C=C4)C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)=O)OC)=NC=C3C(F)(F)F)=C21

Molecular Formula

C52H59F3N8O11S

Molecular Weight

1061.13

References & Citations

[1]Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62 (5) :2508-2520. |[2]Toffoli L, et al. FAK inhibition disrupts tumor growth, apoptosis, and transcriptional regulation in GI-NETs. Endocr Oncol. 2025 Aug 14;5 (1) :e250052.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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BI-0319

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