Products for Research Use Only
RegisterLogin

Osunprotafib

CAT: 1410-M35583-04Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:1410-M35583-04Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors. Osunprotafib (ABBV-CLS-484) stimulates the tumor microenvironment and promotes natural killer cell and CD8 T cell function and enhances T cell anti-tumor immunity by enhancing JAK-STAT signaling and reducing T cell dysfunction.
CAS Number
2489404-97-7
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
385.45
Molecular Formula
C17H24FN3O4S
Notes
Research use only, not for human use.
Receptor
Phosphatase

Chemical Information

Abbv-cls-484

Osunprotafib is a small molecule drug. The usage of the INN stem '-protafib' in the name indicates that Osunprotafib is a human protein tyrosine phosphatase (HPTP) inhibitor. Osunprotafib is under investigation in clinical trial NCT04777994 (Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors). Osunprotafib has a monoisotopic molecular weight of 385.15 Da.

CAS Number2489404-97-7
PubChem CID155103607
IUPAC Name5-[(7R)-1-fluoro-3-hydroxy-7-(3-methylbutylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one
Molecular FormulaC17H24FN3O4S
Molecular Weight385.5
XLogP2.1
Topological Polar Surface Area107
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count26
Formal Charge0
Complexity624
SMILES
CC(C)CCN[C@@H]1CCC2=CC(=C(C(=C2C1)F)N3CC(=O)NS3(=O)=O)O
InChI
InChI=1S/C17H24FN3O4S/c1-10(2)5-6-19-12-4-3-11-7-14(22)17(16(18)13(11)8-12)21-9-15(23)20-26(21,24)25/h7,10,12,19,22H,3-6,8-9H2,1-2H3,(H,20,23)/t12-/m1/s1
InChIKey
DVFCRTGTEXUFIN-GFCCVEGCSA-N
Chemical Structure
2D Structure
2D structure of Abbv-cls-484
CAS: 2489404-97-7
CID: 155103607
Formula: C17H24FN3O4S
MW: 385.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight385.5
XLogP32.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass385.14715559
Monoisotopic Mass385.14715559
Topological Polar Surface Area107 Ų
Heavy Atom Count26
Formal Charge0
Complexity624
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5804400Osunprotafib
T211442-01Osunprotafib hydrochloride
HY-145923BOsunprotafib (hydrochloride)
C01543-1mgOsunprotafib (ABBV-CLS-484)

Popular Products