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Osunprotafib hydrochloride

CAT: 0931-T211442-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211442-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2986745-48-4
Target
Phosphatase
Related Pathways
Metabolism
Bioactivity
Osunprotafib (ABBV-CLS-484) hydrochloride is an orally active, selective inhibitor targeting the active sites of PTPN1 (IC50: 2.5 nM) and PTPN2 (IC50: 1.8 nM) . It shows 6-8 times weaker activity towards PTPN9 and no detectable activity against SHP-1 or SHP-2. This compound enhances the sensitivity of human cancer cell lines to IFNγ. By boosting JAK-STAT signaling and reducing T cell dysfunction, Osunprotafib hydrochloride exhibits potent antitumor immunity.
Smiles
FC=1C(=C(O)C=C2C1C[C@H](NCCC(C)C)CC2)N3CC(=O)NS3(=O)=O.Cl
Molecular Formula
C17H25ClFN3O4S
Molecular Weight
421.92
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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