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Osunprotafib hydrochloride

CAT: 0013-GTR19263831-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263831-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Osunprotafib (ABBV-CLS-484) hydrochloride is an orally active, selective inhibitor targeting the active sites of PTPN1 (IC50: 2.5 nM) and PTPN2 (IC50: 1.8 nM) . It shows 6-8 times weaker activity towards PTPN9 and no detectable activity against SHP-1 or SHP-2. This compound enhances the sensitivity of human cancer cell lines to IFNγ. By boosting JAK-STAT signaling and reducing T cell dysfunction, Osunprotafib hydrochloride exhibits potent antitumor immunity.
CAS Number
2986745-48-4
Field of Research
Metabolism Research
Smiles
FC=1C (=C (O) C=C2C1C[C@H] (NCCC (C) C) CC2) N3CC (=O) NS3 (=O) =O.Cl
Molecular Formula
C17H25ClFN3O4S
Molecular Weight
421.92
Storage Conditions
-20°C
Notes
For research use only.

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