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Osunprotafib

CAT: 0013-GTR19186829-05Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19186829-05Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Osunprotafib (ABBV-CLS-484) is an oral PTP1B/PTPN2 inhibitor in clinical development for oncology. It modulates the tumor microenvironment to enhance anti-tumor immunity by potentiating JAK-STAT signaling in NK and CD8+ T cells, thereby reducing T cell exhaustion, as evidenced in preclinical in vivo studies.
CAS Number
2489404-97-7
Product Name Alternative
Osunprotafib, AC 484, AC 484, ABBV-CLS 484, ABBV-CLS484, ABBV-CLS-484, AC484, AC-484, protein tyrosine phosphatase (PTP)
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.11% (May vary between batches)
Form
Powder
Solubility
DMSO: 56.2 mg/mL (145.9 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble)
Smiles
CC (C) CCN[C@@H]1CCc2cc (O) c (N3CC (=O) NS3 (=O) =O) c (F) c2C1
Molecular Formula
C17H24FN3O4S
Molecular Weight
385.45
Storage Conditions
Powder: -20°C
Notes
For research use only.

Chemical Information

Abbv-cls-484

Osunprotafib is a small molecule drug. The usage of the INN stem '-protafib' in the name indicates that Osunprotafib is a human protein tyrosine phosphatase (HPTP) inhibitor. Osunprotafib is under investigation in clinical trial NCT04777994 (Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors). Osunprotafib has a monoisotopic molecular weight of 385.15 Da.

CAS Number2489404-97-7
PubChem CID155103607
IUPAC Name5-[(7R)-1-fluoro-3-hydroxy-7-(3-methylbutylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one
Molecular FormulaC17H24FN3O4S
Molecular Weight385.5
XLogP2.1
Topological Polar Surface Area107
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count26
Formal Charge0
Complexity624
SMILES
CC(C)CCN[C@@H]1CCC2=CC(=C(C(=C2C1)F)N3CC(=O)NS3(=O)=O)O
InChI
InChI=1S/C17H24FN3O4S/c1-10(2)5-6-19-12-4-3-11-7-14(22)17(16(18)13(11)8-12)21-9-15(23)20-26(21,24)25/h7,10,12,19,22H,3-6,8-9H2,1-2H3,(H,20,23)/t12-/m1/s1
InChIKey
DVFCRTGTEXUFIN-GFCCVEGCSA-N
Chemical Structure
2D Structure
2D structure of Abbv-cls-484
CAS: 2489404-97-7
CID: 155103607
Formula: C17H24FN3O4S
MW: 385.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight385.5
XLogP32.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass385.14715559
Monoisotopic Mass385.14715559
Topological Polar Surface Area107 Ų
Heavy Atom Count26
Formal Charge0
Complexity624
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M35583-01Osunprotafib
T211442-01Osunprotafib hydrochloride
HY-145923BOsunprotafib (hydrochloride)
C01543-1mgOsunprotafib (ABBV-CLS-484)

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