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SPDV

CAT: 0804-HY-129371-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129371-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SPDV is a cleavable ADC linker used for diagnosis and treatment of cancer or B cell proliferative diseas.
CAS Number
317331-86-5
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spdv.html
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(ON1C(CCC1=O)=O)CCCCSSC2=NC=CC=C2
Molecular Formula
C14H16N2O4S2
Molecular Weight
340.43
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Allen J. Ebens, et al. Antibodies and immunoconjugates and uses therefor. WO2007140371A2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Disulfide Cleavable Linker

Chemical Information

N-succinimidyl-5-(2-pyridyldithio)valerate
CAS Number317331-86-5
PubChem CID87534914
IUPAC Name(2,5-dioxopyrrolidin-1-yl) 5-(pyridin-2-yldisulfanyl)pentanoate
Molecular FormulaC14H16N2O4S2
Molecular Weight340.4
XLogP1.4
Topological Polar Surface Area127
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Heavy Atom Count22
Formal Charge0
Complexity404
SMILES
C1CC(=O)N(C1=O)OC(=O)CCCCSSC2=CC=CC=N2
InChI
InChI=1S/C14H16N2O4S2/c17-12-7-8-13(18)16(12)20-14(19)6-2-4-10-21-22-11-5-1-3-9-15-11/h1,3,5,9H,2,4,6-8,10H2
InChIKey
ABQGFYSYSCHJNB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-succinimidyl-5-(2-pyridyldithio)valerate
CAS: 317331-86-5
CID: 87534914
Formula: C14H16N2O4S2
MW: 340.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight340.4
XLogP31.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Exact Mass340.05514934
Monoisotopic Mass340.05514934
Topological Polar Surface Area127 Ų
Heavy Atom Count22
Formal Charge0
Complexity404
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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