TIMP2 / TIMP-2 Protein

CAT: 0209-600-262-L100Size: 100 µgDry Ice: YesHazardous: No
CAT#:0209-600-262-L100Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and they inhibit most MMPs by forming non-covalent binary complex. TIMP2 is a 22 kDa non N-glycosylated protein expressed by a variety of cell types, and plays a unique role among TIMP family members owing to its functions to regulate cellular responses to growth factors. Findings establish an unexpected, MMP-independent mechanism for TIMP2 inhibition of endothelial cell proliferation in vitro and reveal an important component of the antiangiogenic effect of TIMP2 in vivo. TIMP-2 thus is critical to the maintenance of tissue homeostasis and is involved in the regulation of tumor microenvironment.
Synonyms
CSC-21K Protein; DDC8 Protein
Accession Number
NP_003246.1
Reactivity
Human
Cross Reactivity
Human
Assay Protocol
See Datasheet send with the product
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Purity
> 96 % as determined by SDS-PAGE
Bioactivity
Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate MCA-PLGL-DPA-AR-NH2 (R&D Systems, Catalog # ES001) . The IC50 value is < 4 nM.
Length
195
Form
Lyophilized or frozen liquid
Buffer
PBS, pH 7.4
Reconstitution
See Datasheet
Molecular Weight
20 kDa
Storage Conditions
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Host or Source
HEK 293 cells

Related Products

CatalogName
100-431-L1000TIMP-2
100-431TIMP-2
600-259-L100TIMP-1 / TIMP1 Protein (Fc Tag)
600-260-L100TIMP-1 / TIMP1 Protein (His Tag)
100-431-L100TIMP-2
100-431-L500TIMP-2
101-M838TIMP-2
100-431STIMP-2
101-M124TIMP-2
100-431-L250TIMP-2

Alternative Products

CatalogName
P518810TIMP2/TIMP-2 Protein (Human)
E53A06901Recombinant Human TIMP2 / TIMP-2 Protein
PKSH031634Recombinant Human TIMP2/TIMP-2 Protein
P518812TIMP-2; TIMP2 Protein (N-His, Mouse)
P518814TIMP2; TIMP-2 Protein (C-His, Mouse)
P518811TIMP2/TIMP-2 Protein (N-hFc, Human)
P518813TIMP2; TIMP-2 Protein (C-His, Human)
PDEM100296-01Recombinant Mouse TIMP-2/TIMP2 protein (His tag)
PKSH030472Recombinant Human TIMP2/TIMP-2 Protein (Fc Tag)
E53A06670Recombinant Human TIMP2 / TIMP-2 Protein (Fc tag)

Popular Products