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TIMP-2

CAT: 0209-101-M838Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M838Size:100 µg
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Description
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
Synonyms
TIMP2; CSC-21K
NCBI Gene ID
7077
UniProt
P16035
Accession Number
NP_003246
Accession Number mRNA
NM_003255
Chromosomal Location
17q25
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant TIMP-2 protein
Clone
(#2C64)
Applications
Capture Ab
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

UniProtKB · P16035

Metalloproteinase inhibitor 2

TIMP2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16035
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TIMP2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q16121, Q93006, Q9UDF7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Disulfide bond

Ligand

Metal-bindingZinc

Molecular function

Metalloenzyme inhibitorMetalloprotease inhibitorProtease inhibitor

Cellular component

Secreted

Domain

Signal

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