TIMP-2

CAT: 0209-100-431Size: 10 µgDry Ice: NoHazardous: No
CAT#:0209-100-431Size:10 µg
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Description
TIMP-2 is an extracellular inhibitor of MMPs including MMP1, 2, 3, 7, 8, 9, 10, 12, 13, 14, 15, 16 and 19. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP-2 can also act through an MMP-independent mechanism inhibiting endothelial cell proliferation in vitro and demonstrates anti-angiogenic activities in vivo. Recombinant human TIMP-2 is a 21.8 kDa protein containing 194 amino acid residues.
Synonyms
Tissue inhibitor of metalloproteinases 2, CSC-21K
NCBI Gene ID
7077
UniProt
P16035
Accession Number
NP_003246
Accession Number mRNA
NM_003255
Chromosomal Location
17q25
Reactivity
Human
Cross Reactivity
Human
Sequence
CSCSPVHPQQ AFCNADVVIR AKAVSEKEVD SGNDIYGNPI KRIQYEIKQI KMFKGPEKDI EFIYTAPSSA VCGVSLDVGG KKEYLIAGKA EGDGKMHITL CDFIVPWDTL STTQKKSLNH RYQMGCECKI TRCPMIPCYI SSPDECLWMD WVTEKNINGH QAKFFACIKR SDGSCAWYRG AAPPKQEFLD IEDP
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
TIMP-2 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-2 concentration of approximately 0.5 μg/ml, when using an MMP-1 concentration of 1.6 μg/ml.
Length
194
Form
Lyophilized
Molecular Weight
21.8 kDa
Host or Source
E. coli

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