MCP-3 (CCL7)

• Description :

  The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross- reacts across species. Recombinant murine MCP-3 is an 8.5 kDa protein containing 74 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

• Synonyms :

  Ccl7; fic; marc; mcp3; MCP-3; Scya7

• NCBI Gene ID :

  20306

• UniProt :

  Q03366

• Accession Number :

  NP_038682.1

• Accession Number mRNA :

  NM_013654.3

• Chromosomal Location :

  11 C; 11 46.5 cM

• Reactivity :

  Mouse

• Cross Reactivity :

  Mouse, Human

• Sequence :

  QPDGPNASTC CYVKKQKIPK RNLKSYRRIT SSRCPWEAVI FKTKKGMEVC AEAHQKWVEE AIAYLDMKTP TPKP

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract Balb/C mouse spleen MNCs using a concentration range of 10.0-100.0 ng/ml.

• Length :

  74

• Form :

  Lyophilized

• Molecular Weight :

  8.5 kDa

• Host or Source :

  E. coli