MCP-2 (CCL8)

• Description:

  The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross- reacts across species. Recombinant murine MCP-2 is an 8.5 kDa protein containing 74 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

• Synonyms:

  Ccl8; HC14; Mcp2; MCP-2; Scya8; AB023418; 1810063B20Rik

• NCBI Gene ID:

  20307

• UniProt:

  Q9Z121

• Accession Number:

  NP_067418.1

• Accession Number mRNA:

  NM_021443

• Chromosomal Location:

  11 C; 11 47.0 cM

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Mouse, Bacteria

• Sequence:

  GPDKAPVTCC FHVLKLKIPL RVLKSYERIN NIQCPMEAVV FQTKQGMSLC VDPTQKWVSE YMEILDQKSQ ILQP

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-100.0 ng/ml.

• Length:

  74

• Form:

  Lyophilized

• Molecular Weight:

  8.5 kDa

• Host or Source:

  E. coli