MCP-3

• Description:

  MCP3 or CCL7 are two monocyte chemotactic proteins produced by human MG63 osteosarcoma cells. Both MCP3 and CCL7 are members of the CC family of chemokines and share 62% and 71% amino acid sequence identity, respectively, with MCP1. CCL7 also shares 58% amino acid identity with MCP2. CCL7 cDNA encodes a 99 amino acid residue precursor protein from which the Nterminal 23 amino acid residues are cleaved to generate the 76 amino acid residue mature CCL7. Mature CCL7 contains a potential Nlinked and several possible Olinked glycosylation sites. Similarly to other CC chemokines, all three MCP proteins are monocyte chemoattractants. In addition, the three MCPs can chemoattract activated NK cells as well as CD4+ and CD8+ T lymphocytes. All three cytokines have also been shown to attract eosinophils and induce histamine secretion from basophils.

• Synonyms:

  CCL7; FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7

• NCBI Gene ID:

  6354

• UniProt:

  P80098

• Accession Number:

  NP_006264

• Accession Number mRNA:

  NM_006273

• Chromosomal Location:

  17q11.2-q12

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant Human MCP-3

• Clone:

  Goat IgG

• Applications:

  ELISA, WB

• Purification Method:

  Antigen-affinity purified

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

• Form:

  Lyophilized from PBS

• Buffer:

  PBS

• Reconstitution:

  Water

• Storage Conditions:

  The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.

• Host or Source:

  Goat