MCP-3 (CCL7)

• Description:

  The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross- reacts across species. Recombinant human MCP-3 is a 9.0 kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

• Synonyms:

  CCL7; FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7

• NCBI Gene ID:

  6354

• UniProt:

  P80098

• Accession Number:

  NP_006264

• Accession Number mRNA:

  NM_006273

• Chromosomal Location:

  17q11.2-q12

• Reactivity:

  Human

• Cross Reactivity:

  Hasmter, Monkey, Mouse, Human

• Sequence:

  QPVGINTSTT CCYRFINKKI PKQRLESYRR TTSSHCPREA VIFKTKLDKE ICADPTQKWV QDFMKHLDKK TQTPKL

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract BaF3 cells expressing human CCR2 receptor using a concentration range of 300-500 ng/ml.

• Length:

  76

• Form:

  Lyophilized

• Molecular Weight:

  9 kDa

• Host or Source:

  E. coli