FGF-21

• Description:

  FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of β-Klotho as a protein cofactor, signals through the FGFR 1c and 4 receptors, and stimulates insulin-independent glucose uptake by adipocytes. Recombinant Murine FGF-21 is a 20.1 kDa protein containing 182 amino acid residues.

• Synonyms:

  Fibroblast Growth Factor-21, FGFL

• NCBI Gene ID:

  56636

• UniProt:

  Q9JJN1

• Accession Number:

  NP_064397.1

• Accession Number mRNA:

  NM_020013.4

• Reactivity:

  Mouse

• Cross Reactivity:

  Mouse

• Sequence:

  MAYPIPDSSP LLQFGGQVRQ RYLYTDDDQD TEAHLEIRED GTVVGAAHRS PESLLELKAL KPGVIQILGV KASRFLCQQP DGALYGSPHF DPEACSFREL LLEDGYNVYQ SEAHGLPLRL PQKDSPNQDA TSWGPVRFLP MPGLLHEPQD QAGFLPPEPP DVGSSDPLSM VEPLQGRSPS YAS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  ≥ 95% by SDS-PAGE gel and HPLC analyses

• Bioactivity:

  Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells.

• Length:

  182

• Form:

  Lyophilized

• Molecular Weight:

  20.1 kDa

• Host or Source:

  E. coli