FGF-19

• Description:

  The FGF family plays central roles during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-19, a member of the FGF family, is a high affinity heparin dependent ligand for FGFR4. FGF-19 is expressed during the brain development and embryogenesis. Recombinant human FGF-19 is a 21.8 kDa protein containing 195 amino acid residues.

• Synonyms:

  FGF19

• NCBI Gene ID:

  9965

• UniProt:

  O95750

• Accession Number:

  NP_005108.1

• Accession Number mRNA:

  NM_005117

• Chromosomal Location:

  11q13.1

• Reactivity:

  Human

• Cross Reactivity:

  Mouse, Hamster

• Sequence:

  MRPLAFSDAG PHVHYGWGDP IRLRHLYTSG PHGLSSCFLR IRADGVVDCA RGQSAHSLLE IKAVALRTVA IKGVHSVRYL CMGADGKMQG LLQYSEEDCA FEEEIRPDGY NVYRSEKHRL PVSLSSAKQR QLYKNRGFLP LSHFLPMLPM VPEEPEDLRG HLESDMFSSP LETDSMDPFG LVTGLEAVRS PSFEK

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by a cell proliferation assay using balb/c 3T3 cells. The expected ED50 for this effect is 100-150 ng/ml.

• Length:

  195

• Form:

  Lyophilized

• Molecular Weight:

  21.8 kDa

• Host or Source:

  E. coli