FGF-8B

CAT: 0209-100-020-L100Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-100-020-L100Size:100 µg
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Description
FGF-8 (FGF-8b) is a heparin binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF-8; FGF-8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF-8A and B are identical unlike human and mouse FGF8 E and F are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. Recombinant human FGF-8 (FGF-8b) is a 22.4 kDa protein consisting of 193 amino acid residues.
Synonyms
FGF8; AIGF; KAL6; FGF-8; HBGF-8
NCBI Gene ID
2253
UniProt
P55075
Accession Number
NP_149355
Accession Number mRNA
NM_033165
Chromosomal Location
10q24
Reactivity
Human/Murine
Cross Reactivity
Chicken, Mouse, Rabbit, Rat, Hamster, Human
Sequence
MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF- receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
Length
193
Form
Lyophilized
Molecular Weight
22.4 kDa
Host or Source
E. coli

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