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FGF-5

CAT: 0209-100-018-L250Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0209-100-018-L250Size:250 µg
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Description
FGF-5 is a secreted heparin binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-5 binds to FGFR 1c and 2c, and plays a regulatory role in the hair growth cycle. Recombinant human FGF-5 is a 27.6 kDa protein consisting of 252 amino acid residues.
Synonyms
FGF5; HBGF-5; Smag-82
NCBI Gene ID
2250
UniProt
P12034
Accession Number
NP_004455
Accession Number mRNA
NM_004464
Chromosomal Location
4q21
Reactivity
Human
Cross Reactivity
Human
Sequence
MAWAHGEKRL APKGQPGPAA TDRNPIGSSS RQSSSSAMSS SSASSSPAAS LGSQGSGLEQ SSFQWSPSGR RTGSLYCRVG IGFHLQIYPD GKVNGSHEAN MLSVLEIFAV SQGIVGIRGV FSNKFLAMSK KGKLHASAKF TDDCKFRERF QENSYNTYAS AIHRTEKTGR EWYVALNKRG KAKRGCSPRV KPQHISTHFL PRFKQSEQPE LSFTVTVPEK KNPPSPIKSK IPLSAPRKNT NSVKYRLKFR FG
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
Length
252
Form
Lyophilized
Buffer
5 mM Tris, pH 7.2 + 50 mM NaCl
Molecular Weight
27.6 kDa
Host or Source
E. coli

UniProtKB · P12034

Fibroblast growth factor 5

FGF5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P12034
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FGF5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
FGF-5
EC number
—
Processing
Precursor
Secondary accessions
B2R554, O75846, Q3Y8M3, Q8NF90
Protein keywords

Coding sequence diversity

Alternative splicing

Disease

Disease variantProto-oncogene

PTM

Glycoprotein

Molecular function

Growth factorMitogen

Technical term

Proteomics identificationReference proteome

Cellular component

Secreted

Domain

Signal