BD-3

CAT: 0209-100-135-L1000Size: 1000 µgDry Ice: NoHazardous: No
CAT#:0209-100-135-L1000Size:1000 µg
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Description
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The Beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Recombinant Human BD-3 is a 5.1 kDa protein containing 45 amino acid residues.
Synonyms
DEFB103A; BD-3; HBD3; HBP3; DEFB3; HBP-3; hBD-3; DEFB-3; DEFB103
NCBI Gene ID
414325
UniProt
P81534
Accession Number
NP_061131.1
Accession Number mRNA
NM_001081551.2
Chromosomal Location
8p23.
Reactivity
Human
Cross Reactivity
Bacteria, Mouse, Human, Virus
Sequence
GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Exhibits antimicrobial activity against gram-positive bacteria S. aureus and gram-negative P. aeruginosa and E.coli.
Length
45
Form
Lyophilized
Molecular Weight
5.1 kDa
Host or Source
E. coli

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ant-050BD 3
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301317-PEBD3 (Beta-Defensin 3, BD-3, BD 3) (PE)
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301317-APCBD3 (Beta-Defensin 3, BD-3, BD 3) (APC)
301317-FITCBD3 (Beta-Defensin 3, BD-3, BD 3) (FITC)
MBS6451986-01BD3 (Beta-Defensin 3, BD-3, BD 3) (HRP)
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