BD-4

CAT: 0209-100-331-L250Size: 250 µgDry Ice: NoHazardous: No
CAT#:0209-100-331-L250Size:250 µg
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Description
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney. In addition to its direct antimicrobial activities, BD-4 is chemo attractant towards human blood monocytes. Recombinant human BD-4 is a 6.0 kDa protein containing 50 amino acid residues.
Synonyms
DEFB104A; BD-4; DEFB4; hBD-4; DEFB-4; DEFB104; DEFB104B
NCBI Gene ID
140596
UniProt
Q8WTQ1
Accession Number
NP_525128.2
Accession Number mRNA
NM_080389.2
Chromosomal Location
8p23.1
Reactivity
Human
Cross Reactivity
Human
Sequence
EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human monocytes using a concentration range of 0.1-100 ng/ml.
Length
50
Form
Lyophilized
Molecular Weight
6.0 kDa
Host or Source
E. coli

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