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BD-1

CAT: 0209-M10-244SSize: 5 µgDry Ice: NoHazardous: No
CAT#:M10-244SSize:5 µg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Murine BD-1 is a 4.1 kDa protein containing 37 amino acid residues.
Synonyms
Beta-Defensin 1, DEFB1, HBD1
NCBI Gene ID
13214
UniProt
P56386
Accession Number
NP_031869.1
Accession Number mRNA
NM_007843.3
Chromosomal Location
8 A2; 8 10.35 cM
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
DQYKCLQHGG FCLRSSCPSN TKLQGTCKPD KPNCCKS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Not available.
Length
37
Form
Lyophilized
Molecular Weight
4.1 kDa
Host or Source
E. coli

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