BD-5

CAT: 0209-100-038-L100Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-100-038-L100Size:100 µg
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Description
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, six human beta-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Human BD-5 is a 57.8 kDa protein containing 51 amino acid residues.
Synonyms
BD5, DEFB5, DEFB105a, Beta-Defensin 5
NCBI Gene ID
245908
UniProt
Q8NG35
Accession Number
NP_689463.1
Accession Number mRNA
NM_152250.2
Reactivity
Human
Cross Reactivity
Human
Sequence
GLDFSQPFPS GEFAVCESCK LGRGKCRKEC LENEKPDGNC RLNFLCCRQR I
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Not available.
Length
51
Form
Lyophilized
Molecular Weight
5,8 kDa
Host or Source
E. coli

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