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TOB1 (phospho Ser164) Antibody

CAT: 0223-79-925Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-79-925Size:0.1 mg
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Background
This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.
NCBI Gene ID
10140
Swiss Prot
P50616
Accession Number
NP_001230806.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
TOB1 (phospho Ser164) antibody was raised against a peptide sequence around phosphorylation site of Serine 164 (A-V-S (p) -P-T) derived from Human TOB1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
40 kDa
Fragment
IgG
Specificity
The antibody detects endogenous levels of TOB1 only when phosphorylated at serine 164.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Symbol
TOB1
NCBI Official Name
Transducer of ERBB2, 1
NCBI Organism
Homo sapiens
Background Reference 01
Matsuda S., Oncogene 12:705-713 (1996) .
Background Reference 02
Ebert L., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Background Reference 03
Kalnine N., Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Other Product Names
TOB, Transducer of erbB-2 1
Tested Applications
WB, IHC
Protein ID
345197216
Physical Properties
Liquid

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