YB1 (phospho Ser102) Antibody

• Background:

  YB-1 is a nuclear protein that binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors CCAAT-containing Y-box of HLA class II genes. Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs) . Interacts with AKT1, SFRS9, THOC4, MSH2, XRCC5, WRN and NCL. Can bind to DNA as a homomeric form, (EFI-A) n or as a heteromeric form in association with EFI-B. Homodimer in the presence of ATP.

• NCBI Gene ID:

  4904

• Swiss Prot:

  P67809

• Accession Number:

  NP_004550.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  YB1 (phospho Ser102) antibody was raised against a peptide sequence around phosphorylation site of Serine 102 (L-R-S (p) -V-G) derived from Human YB1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  36 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous levels of YB1 only when phosphorylated at serine 102.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  YBX1

• NCBI Official Name:

  Y box binding protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sakura H., Gene 73:499-507 (1988) .

• Background Reference 02:

  Didier D.K. Proc. Natl. Acad. Sci. U.S.A. 85:7322-7326 (1988) .

• Background Reference 03:

  Kolluri R., Nucleic Acids Res. 19:4771-4771 (1991) .

• Other Product Names:

  CBF-A, NSEP1, EFI-A, MSY-1, YBX1

• Tested Applications:

  WB

• Protein ID:

  34098946

• Physical Properties:

  Liquid