TOB1 Antibody

• Background :

  TOB1 is a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.

• NCBI Gene ID :

  10140

• Swiss Prot :

  P50616

• Accession Number :

  P50616

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This TOB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-83 amino acids from the N-terminal region of human TOB1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  38 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  TOB1

• NCBI Official Name :

  Protein Tob1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Suzuki, T., et.al., Genes Dev. 16 (11), 1356-1370 (2002)

• Background Reference 02 :

  Yoshida, Y., et.al., Cell 103 (7), 1085-1097 (2000)

• Other Product Names :

  Protein Tob1, Transducer of erbB-2 1, TOB1, TOB, TROB1

• Tested Applications :

  WB, IHC-P, Flow

• Protein ID :

  1729989

• Physical Properties :

  Liquid