PEA-15 (phospho Ser104) Antibody

• Background:

  Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

• NCBI Gene ID:

  8682

• Swiss Prot:

  Q15121

• Accession Number:

  NP_003759.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  PEA-15 (phospho Ser104) antibody was raised against a peptide sequence around phosphorylation site of Serine 104 (I-P-S (p) -A-K) derived from Human PEA-15.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  19 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous levels of PEA-15 only when phosphorylated at serine 104.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

• Symbol:

  PEA15

• NCBI Official Name:

  Phosphoprotein enriched in astrocytes 15

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Estelles A., J. Biol. Chem. 271:14800-14806 (1996) .

• Background Reference 02:

  Condorelli G., EMBO J. 17:3858-3866 (1998) .

• Background Reference 03:

  Wolford J.K., Gene 241:143-148 (2000) .

• Other Product Names:

  PE15, PEA15, PED

• Tested Applications:

  WB, IHC

• Protein ID:

  32470612

• Physical Properties:

  Liquid