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MAP2K3 (phospho Thr222) Antibody

CAT: 0223-79-854Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-854Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells.
NCBI Gene ID
5606
Swiss Prot
P46734
Accession Number
NP_659731.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
MAP2K3 (phospho Thr222) antibody was raised against a peptide sequence around phosphorylation site of threonine 222 (A-K-T (p) -M-D) derived from Human MAP2K3 .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
39 kDa
Fragment
IgG
Specificity
The antibody detects endogenous levels of MAP2K3 only when phosphorylated at threonine 222.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Symbol
MAP2K3
NCBI Official Name
Mitogen-activated protein kinase kinase 3
NCBI Organism
Homo sapiens
Background Reference 01
Derijard B., Science 267:682-685 (1995) .
Background Reference 02
Moriguchi T., J. Biol. Chem. 271:26981-26988 (1996) .
Background Reference 03
The MGC Project Team; Genome Res. 14:2121-2127 (2004) .
Other Product Names
MAP2K3, MAPKK 3, MEK3, MP2K3, PRKMK3
Tested Applications
WB, IHC
Protein ID
24638466
Physical Properties
Liquid

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