MAP2K4 Antibody

CAT: 0223-79-657Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-79-657Size:0.1 mg
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Background
SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3) . Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop (4) . Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction (5) .
NCBI Gene ID
6416
Swiss Prot
P45985
Accession Number
NP_003001.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
MAP2K4 antibody was raised against a peptide sequence around aa.352~356 (E-S-K-R-P) derived from Human MAP2K4. .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
44 kDa
Specificity
This antibody detects endogenous levels of total MAP2K4 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
MAP2K4
NCBI Official Name
Mitogen-activated protein kinase kinase 4
NCBI Organism
Homo sapiens
Background Reference 01
Davis, R. J. (1994) Trends Biochem. Sci. 19, 470-473. Sanchez, I. et al. (1994) Nature 372, 794-798. Yan, M. et al. (1994) Nature 372, 798-800. Kyriakis, J. M. et al. (1994) Nature 369, 156-160. Park, H. et al. (2002) J. Biol. Chem. 277, 2573-2578.
Other Product Names
JNKK, MEK4, MKK4, SEK1, SKK1, JNKK1, SERK1, MAPKK4, PRKMK4, SAPKK1, SAPKK-1
Tested Applications
WB
Protein ID
4506889
Physical Properties
Liquid

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