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MAP2K2 Antibody

CAT: 0223-63-310Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-310Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.
NCBI Gene ID
5605
Swiss Prot
P36507
Accession Number
P36507
Host
Rabbit
Reactivity
Human
Immunogen
This MAP2K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-229 amino acids from human MAP2K2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Drosophila, Hamster, Mouse, Rabbit, Rat, Xenopus, Chicken
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Symbol
MAP2K2
NCBI Official Name
Dual specificity mitogen-activated protein kinase kinase 2
NCBI Organism
Homo sapiens
Background Reference 01
Burroughs, K.D., et al., Mol. Cancer Res. 1 (4) :312-322 (2003) .
Background Reference 02
Tran, H., et al., Mol. Cell. Biol. 23 (20) :7177-7188 (2003) .
Background Reference 03
Li, S.P., et al., Cancer Res. 63 (13) :3473-3477 (2003) .
Background Reference 04
Li, Y., et al., J. Biol. Chem. 278 (16) :13663-13671 (2003) .
Other Product Names
Dual specificity mitogen-activated protein kinase kinase 2, MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2, MAP2K2, MEK2, MKK2, PRKMK2
Tested Applications
WB, IHC-P
Protein ID
547915
Physical Properties
Liquid

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