MAP2K2 Antibody

• Background:

  MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.

• NCBI Gene ID:

  5605

• Swiss Prot:

  P36507

• Accession Number:

  P36507

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MAP2K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-229 amino acids from human MAP2K2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Drosophila, Hamster, Mouse, Rabbit, Rat, Xenopus, Chicken

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MAP2K2

• NCBI Official Name:

  Dual specificity mitogen-activated protein kinase kinase 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Burroughs, K.D., et al., Mol. Cancer Res. 1 (4) :312-322 (2003) .

• Background Reference 02:

  Tran, H., et al., Mol. Cell. Biol. 23 (20) :7177-7188 (2003) .

• Background Reference 03:

  Li, S.P., et al., Cancer Res. 63 (13) :3473-3477 (2003) .

• Background Reference 04:

  Li, Y., et al., J. Biol. Chem. 278 (16) :13663-13671 (2003) .

• Other Product Names:

  Dual specificity mitogen-activated protein kinase kinase 2, MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2, MAP2K2, MEK2, MKK2, PRKMK2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  547915

• Physical Properties:

  Liquid