C1QA Antibody

• Background:

  C1q. C1q associates with the proenzymes C1R and C1S to yield C1, the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1.

• NCBI Gene ID:

  712

• Swiss Prot:

  P02745

• Accession Number:

  NP_057075.1 (A), NP_000482.2 (B), NP_758957.1 (C)

• Host:

  Chicken

• Reactivity:

  Human

• Immunogen:

  Human plasma C1q protein

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Innate Immunity, Neuroscience

• Purification:

  Antigen affinity-purified

• Concentration:

  1 mg/mL

• Buffer:

  Phosphate-Buffered Saline. No preservatives added.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  C1QA antibody can be stored at 4˚ C for short term (weeks) . Long term storage should be at -20˚ C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  26 kDa (calculated)

• Applications Notes:

  C1q antibody can be used for the detection of C1q by Western blot, ELISA, may also work for IHC and ICC.

• Symbol:

  C1QA

• NCBI Official Name:

  Complement component 1, q subcomponent, A chain

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Leigh, L. E. et al. C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signaling mechanisms Biochem. J. 330 (Pt 1), 247-254 (1998) .

• Other Product Names:

  Complement C1q subcomponent subunit A

• Tested Applications:

  ELISA

• Protein ID:

  7705753 (A), 11038662 (B), 27363488 (C)

• Physical Properties:

  Liquid