FGFR4 Antibody

• Background:

  FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for family members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

• NCBI Gene ID:

  2264

• Swiss Prot:

  P22455

• Accession Number:

  P22455

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This FGFR4 antibody is generated from rabbits immunized with recombinant human FGFR4 protein.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  88 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  FGFR4

• NCBI Official Name:

  Fibroblast growth factor receptor 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jezequel, P., et al., Br. J. Cancer 90 (1) :189-193 (2004) .

• Background Reference 02:

  Qian, Z.R., et al., J. Clin. Endocrinol. Metab. 89 (4) :1904-1911 (2004) .

• Background Reference 03:

  Yu, S., et al., J. Biol. Chem. 278 (22) :19597-19602 (2003) .

• Background Reference 04:

  Becker, N., et al., Cancer Epidemiol. Biomarkers Prev. 12 (6) :582-583 (2003) .

• Other Product Names:

  Fibroblast growth factor receptor 4, FGFR-4, CD334, FGFR4, JTK2, TKF

• Tested Applications:

  WB

• Protein ID:

  13432140

• Physical Properties:

  Liquid