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FGFR4 Antibody

CAT: 0223-63-089Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-089Size:400 µL
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Background
FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for family members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
NCBI Gene ID
2264
Swiss Prot
P22455
Accession Number
P22455
Host
Rabbit
Reactivity
Human
Immunogen
This FGFR4 antibody is generated from rabbits immunized with recombinant human FGFR4 protein.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
88 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FGFR4
NCBI Official Name
Fibroblast growth factor receptor 4
NCBI Organism
Homo sapiens
Background Reference 01
Jezequel, P., et al., Br. J. Cancer 90 (1) :189-193 (2004) .
Background Reference 02
Qian, Z.R., et al., J. Clin. Endocrinol. Metab. 89 (4) :1904-1911 (2004) .
Background Reference 03
Yu, S., et al., J. Biol. Chem. 278 (22) :19597-19602 (2003) .
Background Reference 04
Becker, N., et al., Cancer Epidemiol. Biomarkers Prev. 12 (6) :582-583 (2003) .
Other Product Names
Fibroblast growth factor receptor 4, FGFR-4, CD334, FGFR4, JTK2, TKF
Tested Applications
WB
Protein ID
13432140
Physical Properties
Liquid

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