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FGFR3 Antibody

CAT: 0223-7425-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7425-01Size:0.02 mg
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Background
FGFR3 Antibody: FGFR3 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis (1) . It is required for normal skeleton development and promotes apoptosis in chondrocytes and cancer cell proliferation. FGFR3 protein contains three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain (1,2) . It is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR3 are associated with several diseases, including achondroplasia and hypochondroplasia (3,4) . Mutations in FGFR3 are also a cause of some bladder and cervical cancers (5) .
NCBI Gene ID
2261
Swiss Prot
P22607
Accession Number
NP_001156685
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
FGFR3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1220 - SK-N-SH Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (95%)
Buffer
FGFR3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
FGFR3 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight
Probable post-translational modification
Fragment
IgG
Specificity
FGFR3 antibody is human, mouse and rat reactive. At least three isoforms of FGFR3 are known to exist; this antibody will detect all three.
Symbol
FGFR3
NCBI Official Name
Fibroblast growth factor receptor 3
NCBI Organism
Homo sapiens
Background Reference 01
Keegan K, Johnson DE, and Williams LT. Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3. Proc. Natl. Acad. Sci. USA 1991; 88:1095-9.
Background Reference 02
Turner N and Grose R. Fibroblast growth factor signalling: from development to cancer. Nat. Rev. Cancer 2010; 10:116-29.
Background Reference 03
Superti-Furga A, Eich G, Bucher HU, et al. A glycine 375-to-cysteine substitution in the transmembrane domain of the fibroblast growth factor receptor-3 in a newborn with achondroplasia. Eur. J. Pediatr. 1995; 154:215-9.
Background Reference 04
Bellus GA, McIntosh I, Smith EA, et al. A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia. Nat. Genet. 1995; 10:357-9.
Other Product Names
FGFR3 Antibody: ACH, CEK2, JTK4, CD333, HSFGFR3EX, Fibroblast growth factor receptor 3, FGFR-3
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
254028242
Physical Properties
Liquid

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