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FGFR1 Antibody

CAT: 0223-63-080Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-080Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome.
NCBI Gene ID
2260
Swiss Prot
P11362
Accession Number
P11362
Host
Rabbit
Reactivity
Human
Immunogen
This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 441-470 amino acids from human FGFR1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
92 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FGFR1
NCBI Official Name
Fibroblast growth factor receptor 1
NCBI Organism
Homo sapiens
Background Reference 01
Jiao, J., et al., Arch. Biochem. Biophys. 410 (2) :187-200 (2003) .
Background Reference 02
Fu, L., et al., J. Comp. Neurol. 462 (2) :265-273 (2003) .
Background Reference 03
Lundin, L., et al., Exp. Cell Res. 287 (1) :190-198 (2003) .
Background Reference 04
Kiselyov, V.V., et al., Structure (Camb.) 11 (6) :691-701 (2003) .
Other Product Names
Fibroblast growth factor receptor 1, FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
Tested Applications
WB
Protein ID
120046
Physical Properties
Liquid

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