FGFR1 Antibody

• Background:

  FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome.

• NCBI Gene ID:

  2260

• Swiss Prot:

  P11362

• Accession Number:

  P11362

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 441-470 amino acids from human FGFR1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  92 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  FGFR1

• NCBI Official Name:

  Fibroblast growth factor receptor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jiao, J., et al., Arch. Biochem. Biophys. 410 (2) :187-200 (2003) .

• Background Reference 02:

  Fu, L., et al., J. Comp. Neurol. 462 (2) :265-273 (2003) .

• Background Reference 03:

  Lundin, L., et al., Exp. Cell Res. 287 (1) :190-198 (2003) .

• Background Reference 04:

  Kiselyov, V.V., et al., Structure (Camb.) 11 (6) :691-701 (2003) .

• Other Product Names:

  Fibroblast growth factor receptor 1, FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR

• Tested Applications:

  WB

• Protein ID:

  120046

• Physical Properties:

  Liquid