FGFR2 Antibody

• Background:

  FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in the gene are associated with many craniosynostotic syndromes and bone malformations. The genomic organization of the gene encompasses 20 exons. Alternative splicing in multiple exons, including those encoding the Ig-like domains, the transmembrane region and the carboxyl terminus, results in varied isoforms which differ in structure and specificity. Isoform 1 has equal affinity for aFGF and bFGF but does not bind KGF.

• NCBI Gene ID:

  2263

• Swiss Prot:

  P21802

• Accession Number:

  P21802

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This FGFR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 794-821 amino acids from the C-terminal region of human FGFR2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  92 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  FGFR2

• NCBI Official Name:

  Fibroblast growth factor receptor 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Freeman, K.W., et al., Cancer Res. 63 (19) :6237-6243 (2003) .

• Background Reference 02:

  Goriely, A., et al., Science 301 (5633) :643-646 (2003) .

• Background Reference 03:

  Fomenkov, A., et al., J. Biol. Chem. 278 (26) :23906-23914 (2003) .

• Background Reference 04:

  Katoh, M., et al., Int. J. Mol. Med. 11 (5) :579-583 (2003) .

• Other Product Names:

  Fibroblast growth factor receptor 2, FGFR-2, K-sam, KGFR, Keratinocyte growth factor receptor, CD332, FGFR2, BEK, KGFR, KSAM

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  120049

• Physical Properties:

  Liquid