Products for Research Use Only
RegisterLogin

FGFR4 Antibody

CAT: 0223-63-088Size: 200 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-63-088Size:200 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of the gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
NCBI Gene ID
2264
Swiss Prot
P22455
Accession Number
P22455
Host
Rabbit
Reactivity
Human
Immunogen
This FGFR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-55 amino acids from the N-terminal region of human FGFR4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
88 kDa
Fragment
Rabbit Ig
Symbol
FGFR4
NCBI Official Name
Fibroblast growth factor receptor 4
NCBI Organism
Homo sapiens
Background Reference 01
References for protein:
Background Reference 02
Jezequel, P., et al., Br. J. Cancer 90 (1) :189-193 (2004) .
Background Reference 03
Qian, Z.R., et al., J. Clin. Endocrinol. Metab. 89 (4) :1904-1911 (2004) .
Background Reference 04
Yu, S., et al., J. Biol. Chem. 278 (22) :19597-19602 (2003) .
Other Product Names
Fibroblast growth factor receptor 4, FGFR-4, CD334, FGFR4, JTK2, TKF
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
13432140
Physical Properties
Liquid

Related Products

CatalogName
79-945FGFR4 (phospho Tyr642) Antibody
63-087FGFR2 Antibody
63-084FGFR1 Antibody
14-421FGFR2 Antibody
7425-01FGFR3 Antibody
7425-002mgFGFR3 Antibody
18-480FGFR2 Antibody
43-179Fgf14 Antibody
63-086FGFR2 Antibody
63-080FGFR1 Antibody

Alternative Products

CatalogName
70R-17296FGFR4 antibody

Popular Products