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EphB6 Antibody

CAT: 0223-63-065Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-065Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.
NCBI Gene ID
2051
Swiss Prot
O15197
Accession Number
O15197
Host
Rabbit
Reactivity
Human
Immunogen
This EphB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 990-1021 amino acids from the C-terminal region of human EphB6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
111 kDa
Fragment
Rabbit Ig
Symbol
EPHB6
NCBI Official Name
Ephrin type-B receptor 6
NCBI Organism
Homo sapiens
Background Reference 01
Freywald, A., et al., J. Biol. Chem. 278 (12) :10150-10156 (2003) . Luo, H., et al., J. Clin. Invest. 110 (8) :1141-1150 (2002) . Wilkinson, D.G., Nat Rev Neurosci 2 (3) :155-164 (2001) . Luo, H., et al., J. Immunol. 167 (3) :1362-1370 (2001) . Tang, X.X., et al., Proc. Natl. Acad. Sci. U.S.A. 97 (20) :10936-10941 (2000) .
Other Product Names
Ephrin type-B receptor 6, HEP, Tyrosine-protein kinase-defective receptor EPH-6, EPHB6
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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