EphB1 Antibody

CAT: 0223-63-055Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-055Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families) .
NCBI Gene ID
2047
Swiss Prot
P54762
Accession Number
P54762
Host
Rabbit
Reactivity
Human
Immunogen
This EphB1 antibody is generated from rabbits immunized with a his tag recombinant protein of human EphB1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
110 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
EPHB1
NCBI Official Name
Ephrin type-B receptor 1
NCBI Organism
Homo sapiens
Background Reference 01
Prevost, N., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (14) :9219-9224 (2002) . Wilkinson, D.G., Nat Rev Neurosci 2 (3) :155-164 (2001) . Xu, Q., et al., Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399) :993-1002 (2000) . Holder, N., et al., Development 126 (10) :2033-2044 (1999) . Stein, E., et al., J. Biol. Chem. 273 (3) :1303-1308 (1998) .
Other Product Names
Ephrin type-B receptor 1, ELK, EPH tyrosine kinase 2, EPH-like kinase 6, EK6, hEK6, Neuronally-expressed EPH-related tyrosine kinase, NET, Tyrosine-protein kinase receptor EPH-2, EPHB1, ELK, EPHT2, HEK6, NET
Tested Applications
WB
Protein ID
1706663
Physical Properties
Liquid

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