EphB3 Antibody

• Background :

  Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB3, a member of the Tyr family of protein kinases, is a receptor for members of the ephrin-B family; it binds to both ephrin-B1 and -B2. Expression of this Type I membrane protein is ubiquitous. The protein contains putative domains for 2 fibronectin type III and 1 sterile alpha motif (SAM) .

• NCBI Gene ID :

  2049

• Swiss Prot :

  P54753

• Accession Number :

  P54753

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This EphB3 antibody is generated from rabbits immunized with EphB3 his fusion protein.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Neuroscience, Signal Transduction

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  110 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  EPHB3

• NCBI Official Name :

  Ephrin type-B receptor 3

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Chiu, S.T., et.al., Carcinogenesis 30 (9), 1475-1486 (2009)

• Background Reference 02 :

  Kang, J.U., et.al., BMC Cancer 9, 237 (2009)

• Other Product Names :

  Ephrin type-B receptor 3, EPH-like tyrosine kinase 2, EPH-like kinase 2, Embryonic kinase 2, EK2, hEK2, Tyrosine-protein kinase TYRO6, EPHB3, ETK2, HEK2, TYRO6

• Tested Applications :

  WB, Flow

• Protein ID :

  76803655

• Physical Properties :

  Liquid