EphB6 Antibody

• Background:

  Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.

• NCBI Gene ID:

  2051

• Swiss Prot:

  O15197

• Accession Number:

  O15197

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This EphB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the N-terminal region of human EphB6.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  111 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  EPHB6

• NCBI Official Name:

  Ephrin type-B receptor 6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Freywald, A., et al., J. Biol. Chem. 278 (12) :10150-10156 (2003) .

• Background Reference 02:

  Luo, H., et al., J. Clin. Invest. 110 (8) :1141-1150 (2002) .

• Background Reference 03:

  Wilkinson, D.G., Nat Rev Neurosci 2 (3) :155-164 (2001) .

• Background Reference 04:

  Luo, H., et al., J. Immunol. 167 (3) :1362-1370 (2001) .

• Other Product Names:

  Ephrin type-B receptor 6, HEP, Tyrosine-protein kinase-defective receptor EPH-6, EPHB6

• Tested Applications:

  WB, IHC-P, Flow

• Physical Properties:

  Liquid