CAD Antibody

• Background:

  The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.

• NCBI Gene ID:

  790

• Swiss Prot:

  P27708

• Accession Number:

  P27708

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CAD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 780-809 amino acids from the Central region of human CAD.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  243 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CAD

• NCBI Official Name:

  CAD protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) :

• Background Reference 02:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 03:

  Ahuja, V., et al. J. Inherit. Metab. Dis. 31 (4) :481-491 (2008)

• Background Reference 04:

  Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

• Other Product Names:

  CAD protein, Glutamine-dependent carbamoyl-phosphate synthase, Aspartate carbamoyltransferase, Dihydroorotase, CAD

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  50403731

• Physical Properties:

  Liquid