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CAD Antibody

CAT: 0223-55-636Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-636Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
NCBI Gene ID
790
Swiss Prot
P27708
Accession Number
P27708
Host
Rabbit
Reactivity
Human
Immunogen
This CAD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 780-809 amino acids from the Central region of human CAD.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
243 kDa
Fragment
Rabbit Ig
Symbol
CAD
NCBI Official Name
CAD protein
NCBI Organism
Homo sapiens
Background Reference 01
Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) :
Background Reference 02
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 03
Ahuja, V., et al. J. Inherit. Metab. Dis. 31 (4) :481-491 (2008)
Background Reference 04
Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)
Other Product Names
CAD protein, Glutamine-dependent carbamoyl-phosphate synthase, Aspartate carbamoyltransferase, Dihydroorotase, CAD
Tested Applications
WB, IHC-P, Flow
Protein ID
50403731
Physical Properties
Liquid

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