RASGRF1 Antibody

• Background:

  RASGRF1 is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. Studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory.

• NCBI Gene ID:

  5923

• Swiss Prot:

  Q13972

• Accession Number:

  Q13972

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RASGRF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 907-936 amino acids from human RASGRF1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  145 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  RASGRF1

• NCBI Official Name:

  Ras-specific guanine nucleotide-releasing factor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Iguchi, T., Int. J. Oncol. 31 (2), 285-291 (2007)

• Background Reference 02:

  Holmes, R., Mol. Cell. Biol. 26 (24), 9564-9570 (2006)

• Other Product Names:

  Ras-specific guanine nucleotide-releasing factor 1, Ras-GRF1, Guanine nucleotide-releasing protein, GNRP, Ras-specific nucleotide exchange factor CDC25, RASGRF1, CDC25, GNRP, GRF1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  13124259

• Physical Properties:

  Liquid