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RASSF1 Antibody

CAT: 0223-59-495Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-495Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
NCBI Gene ID
11186
Swiss Prot
Q9NS23
Accession Number
Q9NS23
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This RASSF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the Central region of human RASSF1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RASSF1
NCBI Official Name
Ras association domain-containing protein 1
NCBI Organism
Homo sapiens
Background Reference 01
El-Kalla, M., et al. Oncogene 29 (42) :5729-5740 (2010)
Background Reference 02
Vardi, A., et al. In Vivo 24 (4) :393-400 (2010)
Background Reference 03
Kim, J.H., et al. Virchows Arch. 457 (1) :35-42 (2010)
Background Reference 04
Ahmed, I.A., et al. Cancer Genet. Cytogenet. 199 (2) :96-100 (2010)
Other Product Names
Ras association domain-containing protein 1, RASSF1 {ECO:0000312|EMBL:AAF351282}
Tested Applications
WB
Protein ID
50401686
Physical Properties
Liquid

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