RASGRF1 antibody

• Background :

  The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

• Synonyms :

  Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) |Guanine nucleotide-releasing protein (GNRP) |Ras-specific nucleotide exchange factor CDC25|RASGRF1|CDC25|GNRP|GRF1

• Gene ID :

  5923

• UniProt :

  Q13972

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  Ras protein-specific guanine nucleotide-releasing factor 1

• Target :

  RASGRF1

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC, IF

• Field of Research :

  Cell Division and Proliferation, Signal Transduction

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  145 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC, IF