CDC2 Antibody

• Background:

  CDK1 is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.

• NCBI Gene ID:

  983

• Swiss Prot:

  P06493

• Accession Number:

  P06493

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CDC2 (CDK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-260 amino acids from the C-terminal region of human CDC2 (CDK1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Neuroscience

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  34 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CDK1

• NCBI Official Name:

  Cyclin-dependent kinase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chow, J.P., et al., J. Biol. Chem. 278 (42) :40815-40828 (2003) .

• Background Reference 02:

  Nozoe, T., et al., J. Cancer Res. Clin. Oncol. 129 (9) :498-502 (2003) .

• Background Reference 03:

  Margottin-Goguet, F., et al., Dev. Cell 4 (6) :813-826 (2003) .

• Background Reference 04:

  Yuan, H., et al., J. Virol. 77 (3) :2063-2070 (2003) .

• Other Product Names:

  Cyclin-dependent kinase 1, CDK1, Cell division control protein 2 homolog, Cell division protein kinase 1, p34 protein kinase, CDK1, CDC2, CDC28A, CDKN1, P34CDC2

• Tested Applications:

  WB

• Protein ID:

  334302921

• Physical Properties:

  Liquid