MAPK11 Antibody

• Background:

  P38 beta is a member of the MAP kinase subfamily of Ser/Thr protein kinases. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by changes in osmolarity of the extracellular environment, proinflammatory cytokines and cellular stress. This protein preferentially phosphorylates transcription factor ATF2. It is activated by phosphorylation on threonine and tyrosine by MKK6, and inhibited by pyridinyl-imidazole related compounds. Highest levels of expression are found in the brain and heart, with additional expression in the placenta, lung, liver, skeletal muscle, kidney and pancreas.

• NCBI Gene ID:

  5600

• Swiss Prot:

  Q15759

• Accession Number:

  Q15759

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This MAPK11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-161 amino acids from the Central region of human MAPK11.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  41 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MAPK11

• NCBI Official Name:

  Mitogen-activated protein kinase 11

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .

• Background Reference 02:

  Dunham, I., et al., Nature 402 (6761) :489-495 (1999) .

• Background Reference 03:

  Enslen, H., et al., J. Biol. Chem. 273 (3) :1741-1748 (1998) .

• Background Reference 04:

  Kumar, S., et al., Biochem. Biophys. Res. Commun. 235 (3) :533-538 (1997) .

• Other Product Names:

  Mitogen-activated protein kinase 11, MAP kinase 11, MAPK 11, Mitogen-activated protein kinase p38 beta, MAP kinase p38 beta, p38b, Stress-activated protein kinase 2b, SAPK2b, p38-2, MAPK11, PRKM11, SAPK2, SAPK2B

• Tested Applications:

  WB

• Protein ID:

  134047835

• Physical Properties:

  Liquid